Drug development against Plasmodium, the pathogen that causes malaria, is more difficult to accomplish than drug development against dangerous staphylococcal infections. Which explanation best describes why this is true

Answers

Answer 1

Drug development against Plasmodium, the pathogen that causes malaria, is more difficult to accomplish than drug development against dangerous staphylococcal infections. The best explanation for this is:Unlike staphylococcal infections, malaria caused by Plasmodium, has a more complex life cycle.

It multiplies in the liver and red blood cells of the host, making it more difficult to attack.The following reasons make it more difficult to develop drugs against Plasmodium:Malaria parasites have a more complex life cycle than staphylococcal infections. The parasites grow in the liver and red blood cells of the host, which makes it more difficult to kill them.Malaria parasites rapidly develop resistance to the drugs used to treat them. When the parasites become resistant, it is harder to treat malaria.Malaria is more common in poor countries with limited resources to develop drugs. This makes drug development even more difficult.

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Answer 2

The explanation that best describes why drug development against Plasmodium, the pathogen that causes malaria, is more difficult to accomplish than drug development against dangerous staphylococcal infections is that Plasmodium is a eukaryotic organism with complex life cycles, while Staphylococcus is a prokaryotic organism with a simple life cycle.

This makes drug development against Plasmodium more complex and challenging. Infectious diseases can be caused by bacteria, viruses, parasites, or fungi. Malaria is a parasitic disease caused by Plasmodium, while staphylococcal infections are caused by the bacterium Staphylococcus. The development of drugs against Plasmodium is more difficult than that against dangerous staphylococcal infections due to the following reasons:

Plasmodium is a eukaryotic organism with complex life cycles, while Staphylococcus is a prokaryotic organism with a simple life cycle. This makes drug development against Plasmodium more complex and challenging.

The Plasmodium species have several different stages in their life cycle. They go through a cycle of asexual reproduction in the human host, followed by sexual reproduction in the mosquito vector. This complexity makes drug development more difficult.

Plasmodium has developed resistance to many drugs, making it more difficult to develop effective treatments. It is also difficult to develop a vaccine against Plasmodium, as the parasite has multiple stages and complex life cycles.

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Related Questions

During the process shown above, the two strands of one DNA molecule are unwound. Then, DNA polymerases add complementary nucleotides to each strand which results in the formation of two identical DNA molecules.
\

Answers

Answer:

This question is incomplete as it lacks image, however, it can be answered based on the description. The complete part of the question is:

" This process is known as dna _______. A.) transcription B.) translation C.) cloning D.) replication

The answer is D. replication

Explanation:

DNA replication is the process whereby a DNA molecule is duplicated to form to identical copies of itself. The process of DNA replication is very pivotal and must occur prior to any cell division.

This process follows the semi-conservative model in which the double-stranded DNA molecule unwounds into two separate single strands. The single strands are then used as template for the synthesis of another complementary strands by DNA polymerase enzyme. At the end, the two DNA molecules are identical in base sequence.

solve it according to the question please.
the subject is petroleum, so please solve it regardibg
this.
F- Explain the global carbon-climate cycle during the Cretaceous period. (Write only one paragraph describing what happened during the Cretaceous geological period in order to have good source rocks.)

Answers

During the Cretaceous period, high temperatures and abundant vegetation resulted in increased \(CO_2\) levels, leading to the accumulation of organic matter and the formation of good source rocks for oil and gas.

During the Cretaceous period, spanning from approximately 145 to 66 million years ago, the global carbon-climate cycle played a crucial role in the development of favorable conditions for the formation of good source rocks. The period was characterized by high global temperatures and abundant vegetation, resulting in increased carbon dioxide \((CO_2)\) levels in the atmosphere.

The elevated \(CO_2\) levels fueled vigorous photosynthesis, leading to the accumulation of organic matter in marine and terrestrial ecosystems. As this organic matter was buried and subjected to heat and pressure over millions of years, it transformed into oil and gas, creating potential source rocks. The warm climate and prolific vegetation during the Cretaceous, along with the subsequent geological processes, contributed to the formation of the rich hydrocarbon reserves that are vital to our energy resources today.

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The correct question is:

Explain the global carbon-climate cycle during the Cretaceous period. (Write only one paragraph describing what happened during the Cretaceous geological period in order to have good source rocks.)

this joint is the largest and most complex of the body, and consists of three joints contained within its snyocial cavity

Answers

The most extensive and intricate joint in the body is the knee.

How many different kinds of joint explain?

The structural classification of joints divides them into three categories: fibrous, cartilaginous, & synovial joints. Fibrous joints are those in which collagen-rich, thick connective tissue connects the bones. Sutures is another name for these joints. Cranium joints between bones are made of fibrous tissue.

Which two main types of joints are there?

Diarthrosis, in which liquid is present, & synarthrosis, in which liquid is absent, are the two fundamental structural forms of joint. The synovial joints, also known as diarthroses, are entirely permanent. While some synarthroses are temporary, others are enduring.

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5. Name 3 things bacteria are "notorious" for?

Answers

Answer:

While pathogenic bacteria are notorious for such diseases as cholera, tuberculosis, and gonorrhea, such disease-causing species are a comparatively tiny fraction of the bacteria as a whole. Bacteria are so widespread that it is possible only to make the most general statements about their life history and ecology.

Explanation:

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2. Why do you think soils are thicker in a valley?

Answers

As the residency time on the top of the mountain is different to the valley, there are more compounds that are deposited and dissolved into the soil as there is more time for decomposition. Therefore the soil will be richer and thicker.

on which surfaces did you move the box?

Answers

Answer:

The force of friction between the two surfaces will increase if the two surfaces are pressed harder against each other. Heavy box will press the floor surface harder as compared to the lighter box. That means the force of friction will be more between the heavier box and surface than between the lighter box and surface. Thus, larger force will be needed to push the heavier box than to push the lighter one.


2. Explain why group behavior, such as schooling, is more about individual advantage than group advantage:​

Answers

Answer:

In this particular group behavior, school is more about individual advantage because it focuses more on your own effort or performance rather than teamwork or of your classes performance for example. You accomplish every step or task on your own. For instance when you take a test, you are INDIVIDUALLY taking the test and will be graded based on your individual performance rather than relying on other people.

Explanation:

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color variation over time in rock pocket mouse population answer

Answers

The color variation observed over time in the rock pocket mouse population is a classic example of natural selection and adaptation to the environment. The rock pocket mouse (Chaetodipus intermedius) is found in the southwestern United States, inhabiting rocky environments where its fur coloration plays a crucial role in camouflage and predator avoidance.

The mice exhibit two primary color morphs: a light-colored or sandy-colored morph and a dark-colored or melanistic morph. The color variation is a result of genetic differences in the population, specifically in the melanocortin-1 receptor (Mc1r) gene, which controls pigmentation.

In habitats with light-colored rocks and sandy soil, the light-colored mice are better camouflaged, making them less visible to predators such as birds of prey. On the other hand, in habitats with dark-colored rocks, the dark-colored mice are better camouflaged, offering them a survival advantage.

The color variation in the rock pocket mouse population is an example of natural selection in action, where individuals with advantageous traits have higher survival rates and pass those traits on to subsequent generations. This process ultimately leads to the adaptation and evolution of the population to their specific ecological niche.

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Final answer:

Directional selection, which favors the survival of organisms best adapted to changes in their environment, can lead to color variation over time in populations like the rock pocket mouse. The mouse population, responding to environmental changes such as a shift in the color of their habitat, would gradually adapt by changing their coat color to better camouflage, hence increasing their survival rate.

Explanation:

The question refers to the evolutionary phenomenon known as directional selection, which can cause changes in coloration of a population over time due to changes in their environment. A good example of this is the evolution of the peppered moth during the Industrial Revolution in England. Initially, the moths were predominantly light in color, which allowed them to camouflage with the light-colored trees and lichens. With the advent of industrialization, soot from factories darkened the trees, and the lighter moths became more apparent to predators. Over time, the darker moths had a higher survival rate as they could better blend in with the soot-covered trees, resulting in an increase in their population.

Similarly, such a phenomenon might occur in the rock pocket mouse population. If environmental changes cause the forest floor to change color, the mouse population may adapt through directional selection, gradually shifting their coat color to blend in with their new environment, hence increasing their survival rate.

When natural selection favors the most fit phenotype, it can lead to a shift in the population's genetic variance towards the new phenotype. Therefore, the color variation over time in a rock pocket mouse population would be a result of this type of selection, triggered by changes in their environment.

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The elements or compounds that enter into a chemical reaction are known as

Answers

Answer:

reactants.

Explanation:

A _______ must bind to the template DNA strand to serve as a starting point for polymerization of a new strand.

Answers

A primer must bind to the template DNA strand to serve as a starting point for polymerization of a new strand.

2 and 3 please !!!!!

2 and 3 please !!!!!

Answers

Answer:

iodine or methalyne?

Explanation:

un so like isocpwlsncmepc fpwlff

What does “denature” mean in terms of protein structure?

Answers

Explanation:

Denaturation, in biology, process modifying the molecular structure of a protein. Denaturation involves the breaking of many of the weak linkages, or bonds (e.g., hydrogen bonds), within a protein molecule that are responsible for the highly ordered structure of the protein in its natural (native) state.

How does the article "how to find the next pandemic before it finds us" relate to biology

Answers

The article "How to Find the Next Pandemic Before It Finds Us" is likely to relate to biology in several ways:

Study of Infectious Diseases: Biology encompasses the study of infectious diseases, including the viruses and other pathogens responsible for pandemics. The article may discuss the biology of viruses, their transmission, and the mechanisms by which they cause disease.

Epidemiology and Public Health: Biology plays a crucial role in understanding and responding to pandemics from an epidemiological and public health perspective. The article may explore topics such as disease surveillance, outbreak investigation, and strategies for preventing and controlling the spread of infectious diseases.

Host-Pathogen Interactions: Understanding the biological interactions between pathogens and their host organisms is fundamental to studying pandemics. The article might delve into the molecular and cellular aspects of host-pathogen interactions, immune responses, and the factors that contribute to the emergence and spread of new infectious diseases.

Genomics and Molecular Biology: Advances in genomics and molecular biology have revolutionized our understanding of pathogens and their genetic makeup. The article may discuss how these fields contribute to identifying and monitoring potential pandemic threats by studying the genetic diversity and evolution of pathogens.

One Health Approach: The article might touch upon the concept of "One Health," which recognizes the interconnectedness of human, animal, and environmental health. Biology encompasses the study of zoonotic diseases (diseases that can spread between animals and humans), and the article could highlight the importance of monitoring and understanding zoonotic pathogens to prevent future pandemics.

Overall, the article is likely to explore the biological aspects of pandemics, focusing on the scientific understanding, surveillance, prevention, and response strategies related to infectious diseases.

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Which of the following statements best describes the process of photosynthesis?

Answers

Answer:

Photosynthesis, the process by which green plants and certain other organisms transform light energy into chemical energy. During photosynthesis in green plants, light energy is captured and used to convert water, carbon dioxide, and minerals into oxygen and energy-rich organic compounds.

Explanation:

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In which animal cells is Golgi apparatus most abundant?.

Answers

pancreatic cell. Golgi apparatus which is a organelle of eukaryotic cells is made up of a sequence of flattened, stacked pouches called cisternae.

The linking number (Lk) of a closed-circular, double-stranded DNA molecule is changed by: a. breaking a strand, b. unwinding or rewinding the DNA, c. then rejoining it.

Answers

The linking number of a closed-circular, double-stranded DNA molecule is changed by breaking a strand, unwinding or rewinding the DNA, and then rejoining it. Each of these manipulations alters the degree of supercoiling, which in turn affects the Lk of the molecule.

The linking number (Lk) of a closed-circular, double-stranded DNA molecule is a topological property that describes the number of times the two strands of DNA are intertwined around each other. It is important to note that the Lk of a DNA molecule is conserved, meaning that it cannot be changed unless some sort of topological manipulation is performed on the molecule.


Breaking a strand of DNA will alter the Lk of the molecule, as it changes the number of times the strands are intertwined. For example, if one strand of a double-stranded DNA molecule is broken, the two strands will separate, and the linking number will decrease by one. This is because the number of times the strands are intertwined is reduced by one, as the broken strand is no longer intertwined with the intact strand.

Unwinding or rewinding the DNA molecule can also alter its linking number. This is because the Lk of a DNA molecule is directly proportional to its degree of supercoiling. When the DNA molecule is unwound, the number of times the strands are intertwined is reduced, and the Lk decreases accordingly. Conversely, when the DNA molecule is rewound, the number of times the strands are intertwined increases, and the Lk increases accordingly.

If the DNA molecule is broken and then re-joined after unwinding or rewinding, the linking number will be restored to its original value, as long as the strands are rejoined in the correct orientation. This is because the act of rejoining the broken strand will restore the degree of supercoiling to its original value, and the Lk will be conserved.

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Determine which word best describes the function of
hormones.
A. Protein
B. Molecule
C. Growth
D. Communication

Answers

Its D Communication.

Have a nice day!!

Answer:

d

Explanation:

What causes soil to wash or blow away more easily because soil is not stabilized by plant roots?

Choices are :
A) biological weathering
B) deposition
C) random weathering
D) chemical weathering
E) physical weathering

Answers

Answer:

Is this a multiple choice?

Explanation:

A. Biological Weathering

if multiple choice

E. Physical Weathering

A. Biological Weathering

D. Chemical Weathering

A cellular structure that can be found in each type of cell that is unique to each type of cell, but that has a similar function in both cells. What is the similar function?

Answers

Answer

Complex barrier to the flow of substances out of the cells,and restrictions to inflow of unwanted substances into the cells. The hydrophobic and hydrophilic nature of the cell membrane controls the entry of substances from the extracellular medium into the intracellualr. In addition the polarity restricts certain substance movement across the walls.

Serve as the selective channels  for the  influx of certain substances into the cells, and the out flux of wastes.This is through ion channels for the movements of ions across.

Provide insulation to the cells,to maintain the constant internal temperature,this is through the presence of lipids as( Phospholipids and cholesterol).The latter prevent the clogging of the lipids in the cell membrane therefore preventing frozen up of the cell membrane,providing insulation.

Separation of metabolic process in the cell.

Explanation:

Cell membrane-This is present in all cells.But the variation of its constituents makes it unique to each cell. Although it performs the same role, the location and role the cells it bounded, reflects its  constituents, it is made up of lipids, carbohydrate, protein and cholesterol

What is a common occurrence in the three different glucose-to-pyruvate catabolic pathways?
A. Glucose is reduced by the addition of hydrogen atoms.
B. Phosphorylated sugars are present.
C. There is no net production of ATP.
D. NADH is oxidized to NAD+.

Answers

All three glucose-to-pyruvate catabolic pathways (glycolysis, pentose phosphate pathway, and gluconeogenesis) involve a series of enzymatic reactions that ultimately convert glucose into pyruvate.

The common occurrence in the three different glucose-to-pyruvate catabolic pathways (glycolysis, pentose phosphate pathway, and gluconeogenesis) is the conversion of glucose into pyruvate through a series of enzymatic reactions.In glycolysis, glucose is converted into two molecules of pyruvate. In the pentose phosphate pathway, glucose is converted into ribose-5-phosphate and glyceraldehyde-3-phosphate, both of which can be converted into pyruvate via glycolysis. In gluconeogenesis, pyruvate is converted back into glucose through a series of enzymatic reactions.Overall, these pathways play crucial roles in energy metabolism and the production of various metabolic intermediates required for cell growth and maintenance.

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The introduction of some nonnative species has been helpful. How can initially useful organisms become harmful to an ecosystem?

Answers

Answer:

See explanation

Explanation:

The introduction of nonnative species in an ecosystem maybe both helpful and harmful. Initially, the introduced nonnative species maybe prove helpful in some ways.

As time goes on, the nonnative species begin to compete with the native species for resources in the ecosystem. The nonnative species may outdo the native species in such competition and entirely replace them. This may ultimately lead to a permanent loss of the native species from the ecosystem.

what is one thing that members of the same species can do, that the other peers of organism cannot

what is one thing that members of the same species can do, that the other peers of organism cannot

Answers

Breeding between different species, although possible, is often complicated as it results in infertile or non-viable offspring. This usually occurs due to the difference in the karyotype.

The karyotype is the set of chromosomes that an organism possesses, for example, the human has 23 pairs of chromosomes (46 chromosomes).

For reproduction to be successful and give rise to healthy organisms, the parents must be of the same species (have the same number of chromosomes and these chromosomes must be homologous, i.e. have similar genes).

Therefore, unlike organisms of different species, the reproduction of 2 organisms of the same species can result in fertile offspring capable of reproduction.

Write a summary paragraph on Evolutionary Classification.​

Answers

Answer:

Evolutionary taxonomy, evolutionary systematics or Darwinian classification is a branch of biological classification that seeks to classify organisms using a combination of phylogenetic relationship (shared descent), progenitor-descendant relationship (serial descent), and degree of evolutionary change.

Explanation:

There's not much explaining to do, but comment on my answer if you have any questions.

CAN SOMEONE HELP!! 30 POINTS

If you can please give a reasoning with your answer!!

CAN SOMEONE HELP!! 30 POINTSIf you can please give a reasoning with your answer!!

Answers

Answer:

Your answer should be D. To research molecules in spider venom ...

Explanation:

Right on EDGE 2021 Biomedical/Health

Help pleasee. It’s about protein synthesis.

Help pleasee. Its about protein synthesis.

Answers

Answer: GCU  AAU  GUC

              Ala     Asn   Val

Explanation:

We have a messenger RNA sequence, and the problem is asking for the complementary amino acids for each of the three letters in the sequence.

I used the chart on the right.

GCU

Take the first letter G and then move right on the chart to find C as the second letter. Look for the third letter last where they are listed on the right side.

GCU = Ala

You will follow the same process by finding the first letter, second letter and the third letter, and then see what the amino acid for that particular three-letter sequence.

GCU = Ala

AAU = Asn

GUC = Val

GCU  AAU  GUC

Ala     Asn   Val

How do diffusion and osmosis help amoebas survive?

How do diffusion and osmosis limit the size of a cell?

Answers

By diffusion and osmosis removing their wastes and supplying them with useful substances help amoebas in survive.

How does diffusion and osmosis help a cell survive?

Human existence depends on diffusion and osmosis because they enable cells to passively absorb nutrients and expel waste. This is due to the fact that osmosis and diffusion both entail the net movement of molecules along concentration gradients and as a result, they don't need any energy input to proceed.

Amoeba is assisted in surviving by diffusion and osmosis, which remove their waste and provide them with nutrients. Osmosis and diffusion are both passive processes, meaning they don't need the energy to work.

The maximum size that a single cell may grow to is constrained by diffusion, which only works over a certain distance. Any food and waste requirements of a single-celled microbe, such as an amoeba, may be met through diffusion.

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Contrast apoptosis and cancer.

Answers

Answer:

Apoptosis is a multi-step, multi-pathway cell-death programme that is inherent in every cell of the body. In cancer, the apoptosis cell-division ratio is altered. Cancer treatment by chemotherapy and irradiation kills target cells primarily by inducing apoptosis.

Explanation:

Which process connects glycolysis and the citric acid cycle?
lactic acid formation
acetyl CoA formation
electron transport
Krebs cycle

Answers

The process which connects glycolysis and the citric acid cycle is acetyl CoA formation.

Glycolysis

Glycolysis is the reaction pathway busy which a glucose molecule is converted to two pyruvate molecules with the production of two net ATP molecules.

Citric acid cycle

This is a cyclic reaction pathway in which a mole of acetyl CoA is oxidized to two molecules of carbon (iv) oxide with the production of the reducing equivalents NADH and FADH2 as well as two ATP molecules.

Acetyl CoA formation

The pyruvate from glycolysis is oxidized to an acetyl CoA molecule by the pyruvate dehydrogenase complex. The acetyl CoA produced then enters the citric acid cycle.

Therefore, the process which connects glycolysis and the citric acid cycle is acetyl CoA formation.

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Answer:

It's B

Explanation:

I took one for the team.

Which of the following most accurately describes a cyclin? O It is present in similar concentrations throughout the cell cycle. O It decreases in concentration when MPF activity increases. It activates a Cdk molecule when it is in sufficient concentration. It is activated to phosphorylate by complexing with a Cdk.

Answers

A cyclin is activated to phosphorylate by complexing with a Cdk. This is the most accurate description of a cyclin. It is also essential to note that cyclins have varying concentrations throughout the cell cycle. Cyclins also play an essential role in the regulation of the cell cycle so the correct answer is option

The cell cycle is a sequence of events that lead to the growth and division of a cell. This cycle consists of two distinct stages, interphase and mitosis. Interphase, which is the longer stage, is divided into three phases: G1, S, and G2. Mitosis is also divided into four stages: prophase, metaphase, anaphase, and telophase. In each of these phases, specific molecules are activated, such as cyclins. Cyclins are proteins that play a crucial role in the regulation of the cell cycle. They work with cyclin-dependent kinases (Cdks), which are enzymes that activate or inactivate other proteins by adding or removing phosphate groups. When a cyclin binds to a Cdk, it forms a complex that is capable of phosphorylating specific proteins. This phosphorylation leads to the activation of these proteins, allowing them to perform their functions.

In addition to activating Cdks, cyclins also have varying concentrations throughout the cell cycle. For example, cyclin A is present in higher concentrations during S phase, while cyclin B is present in higher concentrations during mitosis. This variation in cyclin concentrations is essential for regulating the timing and progression of the cell cycle.

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​Which of the following statements is true regarding Cells A and B?

Choose 1 answer:

Choose 1 answer:

(Choice A) Cell A is eukaryotic because it has DNA.

(Choice B) Neither Cell A and Cell B are eukaryotic because they have flagella.

(Choice C) Both Cell A and Cell B are eukaryotic because they have ribosomes.

(Choice D) Cell B is eukaryotic because it has a nucleus.

Which of the following statements is true regarding Cells A and B? Choose 1 answer: Choose 1 answer:

Answers

Answer:

(Choice D) Cell B is eukaryotic because it has a nucleus.

Explanation:

Cell B is unicellular euglena which is eukaryotic organism. While cell A is bacteria which is prokaryotic.

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Bugatti is .............. car in the world. (fast) ?to choose ?fasterthe fastestfast Which set of values could be the side lengths of a 30-60-90 triangle?A. 6, 12, 12\sqrt{3}B. 6, 12, 12\sqrt{2}C. 6, 6\sqrt{3}, 12D. 6, 6\sqrt{2}, 12 Do you think molecules are larger or smaller than a cell in the human body? The Oklahoma governor responsible for halting farm foreclosures and ordering oil well quotas during the early Great DepressionwasA. Herbert HooverB. William MurrayC. E. W. MarlandD. Leon Phillips TRANSLATE THIS TEXT IN SPANISH BUT INCLUDE THE VERB HABERI am taking English, Civics, Biology, and Geometry. In English there are Fourty Students. In Civics there are Thirty Students. In biology there are twenty students. And in geometry there are also twenty students. Examine the two squirrel populations in the following figure. The populations are separated by a geographic barrier. If after a long period of time the two species are no longer separated, what evidence is needed to determine if speciation has occurred?a. Hybrid offspring of the two populations begin to appear.b. One species will increase into a population size twice as large as the other species.c. Polyploidy is creating new species.d. The two populations are not interbreeding freely. A disk is in the form of square and measures 5.25 inches on each side. Findthe diagonal length of the disk? Common stocks of small firms have risk and produce average annual returns than large stock; with the arrual retum on small-company stocks averaging percent and the achual return on large-company stocks areragng Light from red, green and blue spotlights shine on asheet of paper. The paper contains cyan and magentapigments. Which of the three primary light colors will beabsorbed by the pigments?A.RedB.Blue and greenC.Red and blueD.BlueE.Red and GreenF.Green Where will the reflection of A over the y-axis be? Which graph represents 7x - 2y < 5? what events are important to the civil rights movement 1950- 1960 besides rosa parks and martin luther king. How does ""the gettysburg address"" and ""o captain! my captain!"" compare in their use of ethos (the use of authority to persuade the audience to act the right way)? neither the speech or poem rely on the use of ethos. both the speech and poem are equal when it comes to the use of ethos. the poem relies more on ethos than the speech does. the speech relies more on ethos than the poem does. the reader is meant to interpret paul's riding his horse as a______. please help me out here! Thank you! Ill give brainliest! What is the value of StartFraction 1. 6 times 10 Superscript 14 Baseline Over 3. 2 times 10 Superscript 7 Baseline EndFraction in scientific notation? 0. 5 times 10 Superscript 2 5. 0 times 10 Superscript 3 5. 0 times 10 Superscript 6 0. 5 times 10 Superscript 7. 6. What is one way a star with much more mass than the sun can end up?white dwarfred giantneutron starred dwarf How did Thomas Jefferson's book collection become important for the United States? In which situation would hydroponics be most useful for sustainable farming?(1 point)a desert area with limited rainfalla mountainous area facing erosiona tropical area facing deforestationa temperate area with too much direct sunlight whats the main idea of In the Gold Rush of 1849, some one hundred thousand immigrants were lured to California by the promise of gold. Towns and businesses popped up to accommodate the growing population, but a problem remained: how to communicate across the vast reaches of the United States. Three businessmen thought they had an answer: faster mail delivery via the Pony Express, a relay system of horses and riders. The Pony Express made its first delivery on April 14, 1860. Mail from St. Joseph, Missouri, reached San Francisco in just eleven days, rather than a month or more, which was standard for mail delivery at the time. The Pony Express was a short-lived solution, however. After just eighteen months, it was replaced by a national telegraph wire.