where are cell bodies of second order sensory neurons in the dorsal column-medial lemniscus pathway?

Answers

Answer 1

In the dorsal column-medial lemniscus pathway, the cell bodies of second-order sensory neurons are located in the nucleus gracilis and nucleus cuneatus of the medulla oblongata.

The dorsal column-medial lemniscus pathway is a sensory pathway that transmits information about touch, vibration, and proprioception (the sense of body position) from the body to the brain.

This pathway consists of three neurons: first-order, second-order, and third-order neurons. The cell bodies of first-order sensory neurons are located in the dorsal root ganglia of the spinal cord.

These sensory neurons receive sensory information from the periphery and transmit it to the dorsal column nuclei in the medulla oblongata. In the medulla oblongata, the first-order neurons synapse with second-order neurons whose cell bodies are located in the nucleus gracilis and nucleus cuneatus.

These second-order neurons then cross the midline of the brainstem and ascend to the thalamus via the medial lemniscus.

Finally, in the thalamus, the second-order neurons synapse with third-order neurons whose axons project to the primary somatosensory cortex in the postcentral gyrus of the parietal lobe.

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Related Questions

do you think that there is an aesthetic value that could be attached to the hides of the nguni cattle after slaughtering?​

Answers

yes it’s from culture so they believe its aesthetically pleasing

What is the function of the extra cellular matrix in the connective tissue

Answers

Answer: Extracellular matrix provides support and anchorage for the shape of the cells, regulates and determines cells dynamic and behavior including cell survival, cell proliferation, cell polarity, cell differentiation, cell adhesion, and cell migration.

Explanation:

What does it mean when a word ends in -ase? (example: Lactase)
It is a Carbohydrate. It is an Enzyme.
It is a Nucleic Acid

Answers

The answer is Enzyme.

based on the five components of a corporate socially responsible strategy depicted in figure 9.2 in chapter 9, is nestlé’s strategy socially responsible? explain. The Five Components of a Corporate Social Responsibility Strategy Actions to ensure the company operates honorably and ethically Actions to promote workforce diversity Actions to support philanthropy, community service, and better quality of life worldwide A Company's Corporate Social Responsibility Strategy Actions to enhance employee well-being and make the company a great place to work Actions to protect and sustain the environment

Answers

To decide if Nestlé's method is socially responsible primarily based on the five components of a corporate social responsibility (CSR) strategy, we need to assess its movements in each region: Actions to ensure the employer operates honorably and ethically, Actions to sell team of workers variety, Actions to support philanthropy, community carrier, and higher quality of existence worldwide, Actions to enhance employee well-being and make the organization a tremendous vicinity to work, and Actions to defend and maintain the environment

Actions to ensure the employer operates honorably and ethically: Nestlé's commitment to operating ethically is reflected in its Code of Business Conduct, which outlines ideas together with integrity, honesty, and transparency. The business enterprise has implemented various tasks to make certain moral behavior across its operations.

Actions to sell team of workers variety: Nestlé recognizes the significance of the body of workers variety and has implemented applications to foster inclusion and diversity in its group of workers. The organization has initiatives centered on gender stability, cultural variety, and identical possibilities.

Actions to support philanthropy, community carrier, and higher quality of existence worldwide: Nestlé has diverse company tasks and partnerships aimed toward improving first-rate lifestyles in groups international. These tasks encompass promoting nutritious schooling, helping rural improvement, and supplying clean water and sanitation.

Actions to enhance employee well-being and make the organization a tremendous vicinity to work: Nestlé invests in worker well-being through numerous programs, including health and well-being tasks, schooling and improvement opportunities, paintings-life stability projects, and employee aid packages.

Actions to defend and maintain the environment: Nestlé has set environmental sustainability dreams and has implemented measures to lessen its environmental impact. The organization makes a specialty of areas which include water and strength efficiency, waste control, sustainable sourcing, and climate change mitigation.

Based on these additives, Nestlé's method appears to be socially accountable as the corporation takes movements throughout numerous dimensions of CSR. However, it is essential to be aware that assessing an enterprise's typical social responsibility involves a more complete analysis, such as evaluating the effectiveness and impact of these moves, as well as thinking about any criticisms or controversies surrounding the organization's practices.

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The correct question is:

"based on the five components of a corporate socially responsible strategy depicted in figure 9.2 in chapter 9, is Nestlé’s strategy socially responsible? explain. The Five Components of a Corporate Social Responsibility Strategy are Actions to ensure the company operates honorably and ethically Actions to promote workforce diversity Actions to support philanthropy, community service, and better quality of life worldwide A Company's Corporate Social Responsibility Strategy Actions to enhance employee well-being and make the company a great place to work Actions to protect and sustain the environment"

based on the five components of a corporate socially responsible strategy depicted in figure 9.2 in chapter

In which organelle does photosynthesis take place?
A:chloroplast
B:vascular bundle
C:mitochondrion
D:stoma

Answers

Answer: Chloroplast

Explanation:

Answer:
Chloroplast

Based on the data provided for the three stream assessment components, is the overall health and stability of the Little Gunpowder River good, fair, marginal, or poor? Explain how water quality results, physical characteristics, and the stream’s biodiversity and presence of certain macroinvertebrate species support your overall stream health rating.

Answers

Answer:

Macroinvertebrates serve several important functions within the aquatic environment:

They provide a valuable "cleaning" service by scavenging dead or decaying bacteria, plants, and animals, which helps recycle nutrients back into the system.

They are an important food for fish, birds, amphibians and reptiles.

Explanation:

the list could go on and on.

A(n) _______
is a special type of scientific investigation
that is performed under controlled conditions typically
including a dependent and independent variable.

Answers

Answer:

experiment

Explanation:

When you are controlling the conditions it is called an experiment.

An experiment is a special type of scientific investigation that is performed under controlled conditions typically including a dependent and independent variable.

What is scientific investigations?

A scientific investigation is a strategy for posing questions as well as testing potential responses.

Anecdotes are usually the starting point for a scientific investigation. Observations frequently generate questions.

Based on scientific knowledge, a hypothesis is a possible logical answer to a scientific question.

The goals of scientific research are to generate knowledge and provide explanations.

Science investigations are carried out in a variety of settings and by a wide range of individuals. Scientific investigations are carried out in a variety of ways that focus primarily on the collection of various types of evidence.

Thus, an experiment is a sort of scientific investigation which takes place under lab settings and generally involves a dependent as well as independent variable.

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A genetic study conducted over multiple generations found that the frequency of genotypes in the first generation were aa: 0.36, aa: 0.48, and aa: 0.16. in the second generation, genotype frequencies shifted to aa: 0.16, aa: 0.48, and aa: 0.36. according to the hardy-weinberg equilibrium, we can assume: ___________--

Answers

According to the Hardy-Weinberg equilibrium, we can assume that the genetic study conducted over multiple generations did not experience any evolutionary forces such as genetic drift, natural selection, migration, or mutation.

The Hardy-Weinberg equilibrium is a principle in population genetics that describes the conditions under which allele and genotype frequencies remain constant from one generation to the next in a sexually reproducing population. It assumes that certain conditions are met, including a large population size, random mating, no migration, no mutation, and no natural selection.

In the given scenario, the genotype frequencies in the first and second generations are provided. By comparing these frequencies, we can observe that there is a shift in the frequencies of the aa genotype. However, the frequencies of the other genotypes (AA and Aa) remain the same between the two generations.

According to the Hardy-Weinberg equilibrium, if the genotype frequencies remain constant from one generation to the next, the population is not undergoing any evolutionary changes. In this case, the shift in the aa genotype frequencies suggests that the population did not conform to the Hardy-Weinberg equilibrium. This indicates the presence of evolutionary forces such as genetic drift, natural selection, migration, or mutation that caused a change in the genotype frequencies between the generations.3

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Reactive oxygen species, antioxidant mechanisms and serum cytokine levels in cancer patients: impact of an antioxidant treatment

Answers

In this study, the researchers investigated the effects of antioxidant treatment on reactive oxygen species (ROS), antioxidant mechanisms, and serum cytokine levels in cancer patients.  Reactive oxygen species (ROS) play a crucial role in cancer development, and antioxidant mechanisms are vital in preventing cancer from forming.

In cancer patients, ROS production increases, which contributes to tumor progression. Therefore, the use of antioxidants to reduce oxidative stress and ROS production has been suggested as a cancer prevention strategy.In this study, 50 cancer patients were recruited to investigate the effects of antioxidant treatment on ROS levels, antioxidant mechanisms, and serum cytokine levels. The patients were divided into two groups: an antioxidant treatment group and a control group. The antioxidant treatment group received a daily dose of antioxidant supplements for 6 months, while the control group received no treatment.The researchers found that antioxidant treatment significantly reduced ROS levels and increased antioxidant mechanisms in the treatment group compared to the control group.

The researchers measured ROS levels in both groups and found that the antioxidant treatment group had significantly lower ROS levels than the control group. They also measured antioxidant mechanisms and found that the antioxidant treatment group had significantly higher antioxidant mechanisms than the control group. This indicates that antioxidant treatment can reduce oxidative stress and increase antioxidant mechanisms in cancer patients.Furthermore, the researchers measured serum cytokine levels and found that the antioxidant treatment group had significantly lower serum cytokine levels than the control group. This indicates that antioxidant treatment may have anti-inflammatory effects, which can be beneficial for cancer patients since inflammation is a contributing factor in tumor progression.

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drug obtained from plants is :
A] MORPHINE
B] INSULINE
C] ASPIRIN
D] CEPHLOSPORIN

Answers

i think it’s B i coukd be wrong

Which factor is needed for both thunderstorms and hurricanes to form?

Which factor is needed for both thunderstorms and hurricanes to form?

Answers

Answer:

C. rising moist air

Explanation:

for the storm to start/process it needs the moist air in order for both hurricanes and thunderstorms to happen, because the rotation with the moistness creates the storms.

Hope this helps

Answer:

rising, moist air

Explanation:

because it is i got it right on my test

What makes an organism fit for its environment is any trait that helps it survive the longest, even if it doesn't reproduce.

Answers

Answer: A cactus has needles to prevent animals from eating the water out from it.

Explanation:

Which hypothesis contributed to the mistaken idea that protein is the gentic material because?

Answers

Hypothesis contributed to the mistaken idea that protein is the genetic material because, with its 20 different amino acids, protein structure could be more variable than that of c.

What is DNA?Deoxyribonucleic acid is a kind of DNA. All known animals and many viruses contain genetic instructions in the form of a polymer called DNA, which is made up of two polynucleotide chains that coil around one another to form a double helix. Among the four major categories of macromolecules—along with proteins, lipids, and complex carbohydratesnucleic acids are one of the four that are essential for all known forms of life (polysaccharides).How does DNA get created?The chemical building blocks of DNA are called nucleotides. These constituents consist of one of four different nitrogen bases, a phosphate group, a sugar group, and a sugar group.DNA strands are built from chains of nucleotides that are bonded together with the phosphate and sugar groups swapped out.

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Certain insects resemble the twigs of trees on which they live. The probable reason for this resemblance is that


a)the trees caused a mutation to occur

B)no mutations have taken place

C)natural selection has favored this trait

D)the insects needed to camouflage themselves

Answers

Answer:

C) natural selection has favored this trait

Explanation:

What is the cell membrane?

A) the center of the cell
B) the boundary of the cell
C) the energy producer of the cell
D) the substance that fills up the cel

Answers

Answer:

B is the answer

Explanation:

The cell membrane is the boundary of the cell, separating the cell material from the outside environment, hence option B is correct.

What is the function of the cell membrane?

All cells have a cell membrane, also known as a plasma membrane, which separates the interior of the cell from the external environment. A semipermeable lipid bilayer makes up the cell membrane. The movement of materials into and out of the cell is controlled by the cell membrane.

A cell is protected by its cell membrane, also known as the plasma membrane. Additionally, it maintains a constant environment inside the cell, and that membrane serves a variety of purposes. One is to move compounds out of the cell that is harmful as well as nutrients into the cell.

Therefore, the cell membrane is the boundary of the cell.

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How many people have you sacrificed to floor gang and the furries

people sacrificed to floor gang: 2M+

people sacrificed to the furries: i lost count around 748, maybe over 1k about now

Answers

Answer:

I lost count of how many to be honest

Answer:

Thanks for all the gifts :3

Explanation:

How can materials exit a cell by active transport

Answers

Answer:  through protein pumps or exocytosis.

Explanation:

what is genetics in biology?​

Answers

Genetics is a branch of biology concerned with the study of genes, genetic variation, and heredity in organisms. ... He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene.

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I missed you

someone stoled my phone

so I can't comed on brainly

a germinated seed persists as an essential part of a turfgrass plant until the plant produces new seed of its own. True or False

Answers

It is true that until a turfgrass plant produces new seed on its own, a germinated seed remains a vital component of the plant.

Where can you find ligules on plants?

The ligule is a leaf component that connects the blade and sheath of the leaf. It may take a variety of shapes, but typically it looks like a fringe of hairs or a translucent membrane.

What species predominates during winter overseeding?

Due to its quick establishment, high wear tolerance, capacity to withstand close mowing, and medium to fine leaf texture, diploid perennial ryegrass (Lolium perenne L., 2n = 2x = 14) is the most common species used to overseed sport fields.

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Why is the skin considered a excretory organ, but the digestive system isn't a excretory system​

Answers

Answer: because it excretes water, salt, and urea from the body. Because it eliminates waste products by sweating.

Explanation: Skin is also considered as excretory organ because it secretes sweat and salt from our body in the form of liquid.

A strand of DNA contains the bases adenine, cytosine, cytosine, and guanine, in that order. Which would be the order
of the bases on the opposite strand of DNA?
cytosine, adenine, adenine, and thymine
cytosine, thymine, thymine, and adenine
thymine, guanine, guanine, and cytosine
Othymine, adenine, adenine, and cytosine


ITS C ON EDGENUITY 2020

A strand of DNA contains the bases adenine, cytosine, cytosine, and guanine, in that order. Which would

Answers

Answer:

If a strand of DNA contains the bases adenine, cytosine, cytosine and guanine the order  of the bases on the opposite strand is thymine, guanine, guanine and cytosine.

Explanation:

DNA contains a double strand, each of which contains a specific sequence of bases —adenine, thymine, cytosine and guanine— whose order determines the genetic information stored in this nucleic acid.

The sequence of bases on one DNA strand is complementary on the other strand, taking into account the complementarity of bases, i.e. the purines adenine and guanine are complemented by the pyrimidines thymine and cytosine, respectively:  

A = T

G ≡ C

So that the sequence A - C - C - G of one chain is complemented by the sequence T - G - G - C of the other.

    Taking into account the above information, the other options can be discarded, as they do not comply with the complementarity of bases in the DNA.

Answer:

C. thymine, guanine, guanine, and cytosine

Explanation:

This form of water pollution causes bacteria to multiply in the water rapidly causing people who come in contact with this water to become ill, many times with diarrhea.

Answers

Answer:

The correct answer is - water contamination.

Explanation:

Water contamination is a form of water pollution in which water is contaminated or polluted with several microorganisms and pathogens by industrial waste, sewage, animal waste.

It is contaminated when rainwater runoffs from agricultural farms, industrial and sewage dump that brings toxins, wastes, and fertilizers to the water body that help bacteria to multiply and infect the people who come in touch with it.

Radioactive decay ___?

A) produces water
B) produces a transformation from one element to another
C) two of the answers
D) none of the above

Answers

I think it’s None of the above

When elongated, tube –shaped cells from the lining of the intestine are treated with a certain chemical in a dish, the cells sag and becomes round blobs. the internal structures disrupted by this chemical are probably?

Answers

Answer:

When elongated, tube –shaped cells from the lining of the intestine are treated with a certain chemical in a dish, the cells sag and becomes round blobs. the internal structures disrupted by this chemical are probably microtubules

Match each part of the heart with the correct label.

Match each part of the heart with the correct label.

Answers

Answer:

1. Aorta

2. Pulmonary Artery (left)

3. Pulmonary Veins (left)

4. Left Atrium

5. Bicuspid Valve

6. Aortic Semi-Lunar Valve (one of the av valves)

7. Left Ventricle

8. Right Ventricle

9. Tricuspid Valve (one of the av valves)

10. Right Atrium

11. Pulmonary Semi-Lunar Valve

12. Superior Vena Cava

Explanation: is correct

Why does DNA replication occur before mitosis and cell division?

Answers

Answer:

Explanation:

DNA replication needs to occur because existing cells divide to make new cells, so that the DNA needs to be copied before cell division so that each new cell receives a full set of instructions.

DNA replication - It is the process of producing two identical copies of DNA molecules from one original DNA molecule.

The cell cycle is the series of events that lead to a cell's genome duplication and final division into two daughter cells.

It consist of two main phases - Interphase and M phase

DNA replication occurs at the interphase during S phase of the cell cycle.

Mitosis begins after interphase.

DNA replication occurs before mitosis and cell division so that each newly formed daughter cell receive full set of chromosomes as of parent cell in their nucleus. DNA contains  instructions that helps the newly formed cells to operate properly.

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Why does DNA replication occur before mitosis and cell division?

why is alcoholic fermentation important to humans?

Answers

Answer:

The main purpose of alcohol fermentation is to produce ATP, the energy currency for cells, under anaerobic conditions

Explanation:

assume a population has a gene with 2 alleles. all the conditions of hardy weinberg equilibrium (hwe) are met for this gene in this population. the frequencies of the 2 alleles are p and q. which of the following is a prediction that follows from the conditions/assumptions of the hardy weinberg equilibrium model?

Answers

The frequency of the heterozygotes will be 2pq for as long as HWE is maintained in the population, with respect to this gene. (option 2)

This is a prediction that follows from the conditions/assumptions of the Hardy-Weinberg Equilibrium model. In other words, the frequency of heterozygotes (Aa) in a population can be calculated using the equation 2pq, where p and q are the frequencies of the two alleles (A and a) in the population.

This assumes that the population is in HWE, meaning that there is no evolution occurring due to factors such as mutation, gene flow, natural selection, or genetic drift. The HWE model provides a baseline for understanding how allele and genotype frequencies are expected to behave in a population over time.

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Complete Question:

Assume a population has a gene with 2 alleles. All the conditions of Hardy Weinberg equilibrium (HWE) are met for this gene in this population. The frequencies of the 2 alleles are p and q. Which of the following is a prediction that follows from the conditions/assumptions of the Hardy Weinberg Equilibrium model? Pick the one best answer.

The frequency of the heterozygote is either p2 or q 2, depending on which allele is being considered. This is only true if HWE is maintained with respect to this gene. The frequency of the heterozygotes will be 2pq for as long as HWE is maintained in the population, with respect to this gene. p+q = 1, for as long as HWE is maintained in the population, with respect to this gene. The allele frequencies will remain as p2 and q2 for as long as HWE is maintained in the population, with respect to this gene. The frequencies of the genotypes add up to 1.0, for as long as HWE is maintained in the population, with respect to this gene.

Which compound present in insects is composed of the amino acids that provide the Venus Flytrap and sundew with much of their nitrogen?

Answers

Answer:

The correct answer is - protein (provide glutamine amino acid)

Explanation:

As we know and also given that Venus flytrap and sundew get their nitrogen by trapping and dissolving the insects. These plants prey on small insects and flies by attracting them. These insects are digested into amino acids that provide nitrogen to the Venus Flytrap and sundew.

Amino acids are the building blocks of proteins. Protein is the compound that is present in insects, that is composed of amino acids such as glutamine that given nitrogen to these plants.

3. What is the function of a stop codon?
tells ribosomes and tRNA to package the proteins for transport out of the cell
tells ribosomes and tRNA to return to the nucleus of the cell
tells ribosomes and tRNA molecules to attach to a strand of mRNA and begin reading and translating
Otells ribosomes and tRNA to stop reading codons and detach

Answers

The function of a stop codon is that it tells ribosomes and tRNA to stop reading codons and detach. That is option D.

What is ribosomes?

Ribosomes are membrane bound cellular organelles that assists the cell in the synthesis of proteins.

The tRNA which is the transfer ribonucleic acid is located at a specific area in the ribosomes and they help in the translation of messages from the messenger Ribonucleic acid for protein synthesis.

The stop codon is a nucleotide that is located at the messenger RNA. Examples of stop codons found in the mRNA include the following:

UAG,

UAA, and

UGA

During the production of proteins by the ribosomes, the stop codons helps to put this process in check by using a negative feedback mechanism of action.

That is to say, the signalling of the stop codon leads to the inhibition of protein synthesis through telling the ribosomes and tRNA to stop reading codons and detach.

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Which list includes all the steps of a descriptive investigation?OA. Asking questions, making observations, and overcominglimitationsaB. Asking questions, making observations, collecting data, andforming a conclusionoC. Asking questions, making observations, collecting data,comparing, and forming a conclusionD. Asking questions, making observations, experimenting, analyzingdata, and forming a conclusion 4180=8c+1700 solve for c 4 4/54 what is the awnser? 15. My mother .. makes. (make) some coffeeD. Put the verbs in brackets into the correct tense:1. Sam.went... (go) to the circus yesterday.2. I...tak.... (talk) on the telephone at the moment.3. Sally always .. helps.. (help) her mother in the house.4. I...hod... (have) dinner in a restaurant last Friday.5. Listen! The birds ......... (sing) in the garden.6. I often ..buy... (buy) fruit from the greengrocer's.7. My mother ..dioks. (drink) tea now.8. Look at Tom and Jim! They calid. (walk) up the hill.9. That man.louchs. (laugh) at the moment.10. The cat ..lona. (play) with a ball now.11. We always ........... (wear) warm clothes in winter.12. He often ..cat... (eat) a sandwich at lunchtime.13. The sun .6 ct from the west (set) 1. To more successfully tie the chart to the information on operant conditioning in the text, the author should add-O a titleO a captionO a subheadingO a boldface term How many pairs of shoes do teenagers have? To find out, a group of AP Statistics students conducted a survey. They selected a random sample of 20 female students and a separate random sample of 20 male students from their school. Then they recorded the number of pairs of shoes that each student reported having. The data is given in the table.Let 1 the true mean number of pairs of shoes that male students at the school have and 2 the true mean number of pairs of shoes that female students at the school have. You start with 420 mg of isotope which has half life of 20 days. How many mg will be left after 40 days What is not a valid way to introduce yourself? No me llamo _______. Mucho gusto. Soy ______. Mucho gusto. Me llamo ________. Mucho gusto. Mi nombre es ______. Mucho gusto. What is the slope of the line represented by the equation y=-2/3-5x? Explain a consequence of international migration for the sendingcountry and explain a consequence of international migration forthe receiving country. Do the Math If all of a poisonous frog's eggs are genetically engineered right after fertilization to include a gene that prevents poison production, what is the ratio of poisonous to non-poisonous frogs in the offspring? A 50-kg person riding a bike puts all her weight on each pedal when climbing a hill. The pedals rotate in a circle of radius 16 cm . Part A What is the maximum torque she exerts True or false: The cost of land owned by a business is recorded in the Land account and this account is classified as an expense. The state of a spin 1/2 particle in Sx basis is defined as () = c+l + x) + i/7 l - x) a) Find the amplitude c+ assuming that it is a real number and the state vector is properly defined. b) Find the expectation value . c) Find the uncertainty SX. Denny Corporation is considering replacing a technologically obsolete machine with a new state-of-the-art numerically controlled machine. The new machine would cost $310,000 and would have a ten-year useful life. Unfortunately, the new machine would have no salvage value. The new machine would cost $52,000 per year to operate and maintain, but would save $93,000 per year in labor and other costs. The old machine can be sold now for scrap for $31,000. The simple rate of return on the new machine is closest to (Ignore income taxes.): Multiple Choice 3.58% 30.00% 7.17% 3.23% IFRS 16 requires that the lessee should capitalize the asset-in-use. 1 What is the exception to this rule (in which case(s) a lessee dose not capitalize the lease)? Provide brief answer. Briefly explain, how the lessee will account for the lease payments. 2 On her way to college, Julia thinks about why it's so important for her to accomplish her goals of graduating from college, becoming a writer, and being well-traveled. In Julia's mind, achieving these goals is not so much for her, but for Am, Ap, and Olga as well. " What a waste their journeys would be if I just settled for a dull, mediocre life. Maybe one day they'll realize that." Through the lens of Julia as a first-generation Mexican American, in what ways will Julia's goals, once reached, change her, her family, and her culture? Question ModeMultiple Select QuestionSelect all that applySelect all the characteristics of life.Multiple select question.evolutionhomeostasis, or maintenance of internal constancyenergy usesolubility in waterreproduction, growth, and developmentorganization A box shaped like a rectangular prism has a length of 8 inches and width of 8 inches. Its volume is 512 cubic inches. What is the height of the box? The process of developing a new combinations of the other factors of production is called productivity. distribution. entrepreneurship. allocation. specialization.